Dichloromethane → HCID 131727223, compound

Participants

Reaction Steps

200 mg (0.542 mmol) of 2-[4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-piperidinyl]-2-oxoethanamine hydrochloride was dissolved in 1.5 ml of dichloromethane. 137 mg (1.36 mmol) of triethylamine was added to the obtained solution. Then a solution of 86.1 mg (0.650 mmol) of (S)-2,2-dimethylcyclopropanecarboxylic acid chloride in 0.5 ml of dichloromethane was slowly added to the obtained mixture. After stirring for 1 hour, the obtained mixture was roughly purified by the silica gel chromatography (dichloromethane: methanol=98: 2) and then purified by the silica gel chromatography (Chromatorex™ NH, Fuji Silysia Chemical LTD., hexane ethyl acetate=92:8 to 1:4) to obtain the title compound.

Provenance & Evidence