HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 11682790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 11719155 | HCID 11719155 | — |
| Solvent | 2-Oxopropiononitrile | HCID 69430 | — |
| Product | HCID 11682790 | HCID 11682790 | 80% |
Reaction Steps
0.26 mmol of 3-Cyano-2-[(1-phenyl-methanoyl)-amino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester are dissolved in 10 ml AcCN/H20 (2/1) and 0.1 eq PTSA is added. After stirring over night, some triethylamine is added and the solvent removed. Recrystalization from ethanol gives the desired product in 80% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714134B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-352d7a9e33584e098a83259a32b69739 |
| Source note | uspto-grants-2010_05 |