Sodium Hydroxide → HCID 11688703, compound

HRID 2236088Notes

Reaction equation

[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12](=[O:18])[CH2:13][O:14]C(=O)C)[CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:21])#[N:2].[OH-].[Na+]>>[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12](=[O:18])[CH2:13][OH:14])[CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20](=[O:21])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)#[N:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 11646661HCID 11646661, compound

Product 1

HCID 11688703HCID 11688703, compound

Procedure

Acetic acid 2{3-cyano-2-[(1-phenyl-methanoyl)-amino]-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl}-2-oxo-ethyl ester is stirred on 1N NaOH over night at room temperature. Workup as described in general procedure A3 gives the desired product.

Sources & evidence

ORD record: ord-5898f3bee8744064b83106881645a4e0
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07714134B2

Reaction notes

Loading…