HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Methyl-1H-imidazole-1-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (2-Methyl-imidazol-1-yl)-acetic acid methyl ester | HCID 28940036 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Methyl-1H-imidazole-1-ethanol | HCID 74169 | — |
Reaction Steps
A solution of (2-methyl-imidazol-1-yl)-acetic acid methyl ester (2.6 g) in diethyl ether (39 ml) is added drop wise to a suspension of LiAlH4 (1.3 g) in 130 ml diethyl ether (130 ml) at 0° C. After 1 hour 1.3 g water, 1.3 g 15% NaOH and 4 g water is added and the slurry stirred for 1 hour. After addition of MgSO4 and filtration the filter cake is washed several times with hot ethyl acetate. After removal of the solvent, the crude product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714135B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-34ab5af199ca4c3bb50435141aa7bb78 |
| Source note | uspto-grants-2010_05 |