Sodium Hydroxide → HCID 11653874, compound

Participants

Reaction Steps

Step b): A solution of crude ethyl (2-benzoyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-acetate (0.085 mmol) in THF (0.5 ml) is treated with 0.2 N aqueous NaOH solution (0.64 ml) at rt for 15 min. Then, the yellow reaction mixture is diluted with water (2 ml), washed with diethyl ether (2 ml), acidified with conc. HCl to pH 1 and extracted with dichloromethane. The combined organic phases are washed with water, then dried over Na2SO4, filtered and the solvent evaporated. The crude product is recrystallized from diisopropyl ether to give pure title compound as yellow solid: tR (LC-1) 2.95 min; ESI-MS positive ion): m/z 335.17 [M+H]+ (calcd 334.37 for C20H18N2O3).

Provenance & Evidence