Water → HCID 68582408, compound

Participants

Reaction Steps

In 8 ml of acetonitrile were dissolved 0.78 g (3.88 mmol) of 3-chloro-1,2-benzoisothiazole 1,1-dioxide and 0.50 g (3.88 mmol) of (3-methylisothiazol-5-yl)methanol. To the resulting solution was dropwise added 0.51 g (5.0 mmol) of triethylamine, followed by stirring at room temperature for 5 hours to give rise to a reaction. After the completion of the reaction, 16 ml of water was added. The resulting crystals were obtained by filtration and washed with water and isopropyl alcohol to obtain 0.30 g (yield: 26%) of 3-(3-methylisothiazol-5-ylmethoxy)-1,2-benzoisothiazole 1,1-dioxide as a light brown powder (melting point: 202 to 204° C.)

Provenance & Evidence