Pyrrolidine → 3-Azulen-1-ylmethylene-2-oxo-2,3-dihydro-1H-indole-5-sulfonicacid dimethylamide

Participants

Reaction Steps

0.504 g 2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid dimethylamide (0.0021 mole) and 0.323 g azulene aldehyde (0.0021 mole) were dissolved in 30 mL dried ethanol. 1.5 mL pyrrolidine (1M) was then added and uniformly stirred at reflux temperature for two hours. After removal of dried ethanol, the results were extracted by dichloromethane and citric acid aqueous solution. The organic layer was collected, dried with anhydrous magnesium sulfate, filtered, concentrated under vacuum, and separated by silica gel column chromatography to give Compound 050 (E-form (0.0548 g), Z-form (0.1376 g)).

Provenance & Evidence