Butyryl chloride → HCID 25006168, compound

HRID 2236132Notes

Reaction equation

HRID 2236132 reaction equation
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[NH2:7][CH:8]([CH:12]([CH3:14])[CH3:13])[C:9]([O-:11])=[O:10].[Na+]>>[C:1]([O:10][C:9](=[O:11])[CH:8]([NH2:7])[CH:12]([CH3:14])[CH3:13])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 8855Butyryl chloride2×HCID 23683721HCID 23683721, compound

Product 1

HCID 25006168HCID 25006168, compound

Procedure

Finally, in a dry 2-necked, round bottomed flask, fixed with a separatory funnel, containing 6.39 g (60 mmol) of the prepared butyryl chloride, and side arm water condenser fixed with a dry receiving flask, is placed 9.18 g (66 mmol) of sodium 2-amino-3-methylbutanoate. The round bottomed flask is placed in an ice bath and the butyryl chloride is added drop wise. After addition is completed the mixture is shaken and the ice bath is replaced by a heating mantle. The flask is then heated until no more solution is dropping into the receiving flask. This crude distillate is then further fractionally distilled to yield 2-amino-3-methylbutanoic butyric anhydride.

Workup

  1. customFinally, in a dry 2-necked, round bottomed flask, fixed with a separatory funnel
  2. customThe round bottomed flask is placed in an ice bath
  3. additionAfter addition
  4. temperatureThe flask is then heated until no more solution
  5. distillationThis crude distillate is then further fractionally distilled

Sources & evidence

ORD record
ord-a779a5dd5ce547328753413b95607236
Source dataset
uspto-grants-2010_05
Patent number
US07714154B2

Reaction notes

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