HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitropyridine → (S)-1-(5-Aminopyridin-2-yl)pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 6-(Morpholino)pyridin-3-amine | HCID 104059 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Reactant | 1-(5-Aminopyridin-2-yl)pyrrolidin-3-ol | HCID 53408167 | — |
| Product | (S)-1-(5-Aminopyridin-2-yl)pyrrolidin-3-ol | HCID 53255820 | — |
Reaction Steps
With a method similar to that used for the preparation of 6-morpholin-4-yl-pyridin-3-ylamine above, 1-(5-amino-pyridin-2-yl)-pyrrolidin-3-ol was prepared from 2-chloro-5-nitro-pyridine and (S)-pyrrolidin-3-ol. LCMS calcd for C9H13N3O (m/e) 179, obsd 180 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714126B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-ab496379b0ee44a29852a69a93375f51 |
| Source note | uspto-grants-2010_05 |