HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(3-Methoxy-azetidin-1-yl)-5-nitro-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(5-Nitropyridin-2-yl)azetidin-3-ol | HCID 52937264 | — |
| Product | 2-(3-Methoxy-azetidin-1-yl)-5-nitro-pyridine | HCID 59301362 | 119.5% |
Reaction Steps
1-(5-Nitro-pyridin-2-yl)-azetidin-3-ol (97.5 mg, 0.5 mmol) was treated with 60% NaH in oil (40 mg, 1 mmol) and methyl iodide (125 uL, 2 mmol) as above to yield 125 mg of crude product that was used without further purification. ES-MS calcd for C9H11N3O3 (m/e) 209.21, obsd 210 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714126B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-96e1d8c49007425c97346a8d23e2b3d0 |
| Source note | uspto-grants-2010_05 |