6-(Morpholino)pyridin-3-amine → 4-Phenyl-thiazole-2-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

HRID 2236209Notes

Reaction equation

HRID 2236209 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:12]([OH:14])=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:15]1([C:21]2[N:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([C:21]2[N:26]=[CH:25][C:24]([NH:27][C:12]([C:9]3[S:10][CH:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=3)=[O:14])=[CH:23][CH:22]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 1040596-(Morpholino)pyridin-3-amineHCID 38785394-Phenylthiazole-2-carboxylic acid

Product 1

HCID 167570134-Phenyl-thiazole-2-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

Procedure

With a procedure similar to example 1 above, 4-phenyl-thiazole-2-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide was prepared from 4-phenyl-thiazole-2-carboxylic acid and 6-morpholin-4-yl-pyridin-3-ylamine. LCMS calcd for C19H18N4O2S (m/e) 366, obsd 367 (M+H).

Sources & evidence

ORD record
ord-af5138dec32b46fa8161809c82a392bf
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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