5-Phenyl-2-(trifluoromethyl)furan-3-carboxylic acid → 5-Phenyl-2-trifluoromethyl-furan-3-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

HRID 2236213Notes

Reaction equation

HRID 2236213 reaction equation
[C:1]1([C:7]2[O:11][C:10]([C:12]([F:15])([F:14])[F:13])=[C:9]([C:16]([OH:18])=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[NH:20][C:21]1[CH:22]=[N:23][C:24]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[CH:25][CH:26]=1>>[N:27]1([C:24]2[N:23]=[CH:22][C:21]([NH:20][C:16]([C:9]3[CH:8]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:11][C:10]=3[C:12]([F:13])([F:14])[F:15])=[O:18])=[CH:26][CH:25]=2)[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 27764365-Phenyl-2-(trifluoromethyl)furan-3-carboxylic acidHCID 59619060N-methyl-6-(morpholin-4-yl)pyridin-3-amine

Product 1

HCID 167571055-Phenyl-2-trifluoromethyl-furan-3-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

Procedure

With a procedure similar to example 1 above, 5-phenyl-2-trifluoromethyl-furan-3-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide was prepared from 5-phenyl-2-trifluoromethyl-furan-3-carboxylic acid and methyl-(6-morpholin-4-yl-pyridin-3-yl)-amine. LCMS calcd for C21H18F3N3O3 (m/e) 417, obsd 418 (M+H).

Sources & evidence

ORD record
ord-1a1582b74a5b41db9984ec122c20b648
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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