5-Chloro-2-phenyl-oxazole-4-carboxylic acid → 5-Chloro-2-phenyl-oxazole-4-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

HRID 2236214Notes

Reaction equation

HRID 2236214 reaction equation
[Cl:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13]([OH:15])=O.C[NH:17][C:18]1[CH:19]=[N:20][C:21]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[CH:22][CH:23]=1>>[N:24]1([C:21]2[N:20]=[CH:19][C:18]([NH:17][C:13]([C:3]3[N:4]=[C:5]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[O:6][C:2]=3[Cl:1])=[O:15])=[CH:23][CH:22]=2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 593012785-Chloro-2-phenyl-oxazole-4-carboxylic acidHCID 59619060N-methyl-6-(morpholin-4-yl)pyridin-3-amine

Product 1

HCID 167571065-Chloro-2-phenyl-oxazole-4-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide

Procedure

With a procedure similar to example 1 above, 5-chloro-2-phenyl-oxazole-4-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide was prepared from 5-chloro-2-phenyl-oxazole-4-carboxylic acid and methyl-(6-morpholin-4-yl-pyridin-3-yl)-amine. LCMS calcd for C19H17ClN4O3 (m/e) 384, obsd 385 (M+H).

Sources & evidence

ORD record
ord-8284cd6a14ff421b964634aefe0dea4a
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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