2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 16757298, compound

HRID 2236217Notes

Reaction equation

HRID 2236217 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][C:21](=[O:32])[CH2:22][N:23]([C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1)[CH3:24]>>[CH3:19][O:20][C:21](=[O:32])[CH2:22][N:23]([CH3:24])[C:25]1[CH:30]=[CH:29][C:28]([NH:31][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301357HCID 59301357, compound

Product 1

HCID 16757298HCID 16757298, compound

Procedure

With a procedure similar to example 1 above, (methyl-{5-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-pyridin-2-yl}-amino)-acetic acid methyl ester was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and [(5-amino-pyridin-2-yl)-methyl-amino]-acetic acid methyl ester. LCMS calcd for C20H17F3N4O4 (m/e) 434, obsd 435 (M+H).

Sources & evidence

ORD record
ord-fb01b1ec95924c9b86076ab28430bcd2
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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