2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301428, compound

HRID 2236221Notes

Reaction equation

HRID 2236221 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:30][CH2:29][CH:28]([N:31]([CH3:35])[C:32](=[O:34])[CH3:33])[CH2:27]2)=[N:24][CH:25]=1>>[C:32]([N:31]([CH3:35])[CH:28]1[CH2:29][CH2:30][N:26]([C:23]2[N:24]=[CH:25][C:20]([NH:19][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:21][CH:22]=2)[CH2:27]1)(=[O:34])[CH3:33]

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301347HCID 59301347, compound

Product 1

HCID 59301428HCID 59301428, compound

Procedure

With a procedure similar to example 1 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[3-(acetyl-methyl-amino)-pyrrolidin-1-yl]-pyridin-3-yl}-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N-[1-(5-amino-pyridin-2-yl)-pyrrolidin-3-yl]-N-methyl-acetamide. LCMS calcd for C23H22F3N5O3 (m/e) 473, obsd 474 (M+H).

Sources & evidence

ORD record
ord-58352dac58b34f79806ca02cb2bfaeba
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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