5-Chloro-2-phenyl-oxazole-4-carboxylic acid → 5-Chloro-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide

HRID 2236224Notes

Reaction equation

HRID 2236224 reaction equation
[Cl:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13]([OH:15])=O.[NH2:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]([CH3:27])[C:24](=[O:26])[CH3:25])=[N:21][CH:22]=1>>[C:24]([N:23]([CH3:27])[C:20]1[N:21]=[CH:22][C:17]([NH:16][C:13]([C:3]2[N:4]=[C:5]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:6][C:2]=2[Cl:1])=[O:15])=[CH:18][CH:19]=1)(=[O:26])[CH3:25]

Participants

3

Reactant 2

HCID 593012785-Chloro-2-phenyl-oxazole-4-carboxylic acidHCID 59301435N-(5-aminopyridin-2-yl)-N-methylacetamide

Product 1

HCID 593014545-Chloro-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide

Procedure

With a procedure similar to example 16 above, 5-chloro-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide was prepared from 5-chloro-2-phenyl-oxazole-4-carboxylic acid and N-(5-amino-pyridin-2-yl)-N-methyl-acetamide. LCMS calcd for C18H15ClN4O3 (m/e) 370, obsd 371 (M+H).

Sources & evidence

ORD record
ord-26f2a635f4254db39f34476f08d2adc4
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

Loading…