2-Phenyl-5-ethyl-oxazole-4-carboxylic acid → 5-Ethyl-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide

HRID 2236225Notes

Reaction equation

HRID 2236225 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:5][C:4]=1[C:14]([OH:16])=O)[CH3:2].[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]([CH3:28])[C:25](=[O:27])[CH3:26])=[N:22][CH:23]=1>>[C:25]([N:24]([CH3:28])[C:21]1[N:22]=[CH:23][C:18]([NH:17][C:14]([C:4]2[N:5]=[C:6]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[O:7][C:3]=2[CH2:1][CH3:2])=[O:16])=[CH:19][CH:20]=1)(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 150939472-Phenyl-5-ethyl-oxazole-4-carboxylic acidHCID 59301435N-(5-aminopyridin-2-yl)-N-methylacetamide

Product 1

HCID 593013065-Ethyl-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide

Procedure

With a procedure similar to example 16 above, 5-ethyl-2-phenyl-oxazole-4-carboxylic acid [6-(acetyl-methyl-amino)-pyridin-3-yl]-amide was prepared from 5-ethyl-2-phenyl-oxazole-4-carboxylic acid and N-(5-amino-pyridin-2-yl)-N-methyl-acetamide. LCMS calcd for C20H20N4O3 (m/e) 364, obsd 365 (M+H).

Sources & evidence

ORD record
ord-03641b2f7d55473fba07cf652c5070d1
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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