2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301420, compound

HRID 2236228Notes

Reaction equation

HRID 2236228 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH:21]1[CH2:25][CH2:24][N:23]([C:26]2[N:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=2)[CH2:22]1>>[CH3:19][O:20][CH:21]1[CH2:25][CH2:24][N:23]([C:26]2[N:31]=[CH:30][C:29]([NH:32][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:28][CH:27]=2)[CH2:22]1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301332HCID 59301332, compound

Product 1

HCID 59301420HCID 59301420, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(3-methoxy-pyrrolidin-1-yl)-pyridin-3-yl]-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and 6-(3-methoxy-pyrrolidin-1-yl)-pyridin-3-ylamine. LCMS calcd for C21H19F3N4O3 (m/e) 432, obsd 433 (M+H).

Sources & evidence

ORD record
ord-64df3b68d8914d94b4b6eccf3b9f70b5
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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