2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301415, compound

HRID 2236232Notes

Reaction equation

HRID 2236232 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1>>[CH3:19][O:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]1[N:26]=[CH:27][C:28]([NH:31][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 23391808HCID 23391808, compound

Product 1

HCID 59301415HCID 59301415, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(3-methoxy-propylamino)-pyridin-3-yl]-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-(3-methoxy-propyl)-pyridine-2,5-diamine. LCMS calcd for C20H19F3N4O3 (m/e) 420, obsd 421 (M+H).

Sources & evidence

ORD record
ord-b4d20173877942bd80ec75856dd78c35
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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