2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 57398504, compound

HRID 2236233Notes

Reaction equation

HRID 2236233 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:19]1([C:25]2[S:26][C:27]([NH2:30])=[CH:28][N:29]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[N:19]1([C:25]2[S:26][C:27]([NH:30][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:28][N:29]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 66520644HCID 66520644, compound

Product 1

HCID 57398504HCID 57398504, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (2-morpholin-4-yl-thiazol-5-yl)-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and 2-morpholin-4-yl-thiazol-5-ylamine. LCMS calcd for C18H15F3N4O3S (m/e) 424, obsd 425 (M+H).

Sources & evidence

ORD record
ord-0f65384fea2c44e6aa4e2a52da064cb3
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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