2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301412, compound

HRID 2236234Notes

Reaction equation

HRID 2236234 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH3:30])[C:24]1[S:25][C:26]([NH2:29])=[CH:27][N:28]=1>>[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH3:30])[C:24]1[S:25][C:26]([NH:29][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:27][N:28]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 67536923HCID 67536923, compound

Product 1

HCID 59301412HCID 59301412, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {2-[(2-methoxy-ethyl)-methyl-amino]-thiazol-5-yl}-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-thiazole-2,5-diamine. LCMS calcd for C18H17F3N4O3S (m/e) 426, obsd 427 (M+H).

Sources & evidence

ORD record
ord-4b661f38aa5640db962dc3bc0f227ce2
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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