2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301431, compound

HRID 2236235Notes

Reaction equation

HRID 2236235 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH2:21][C@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[C:27]1[N:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=1>>[CH3:19][O:20][CH2:21][C@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[C:27]1[N:32]=[CH:31][C:30]([NH:33][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301404HCID 59301404, compound

Product 1

HCID 59301431HCID 59301431, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-((R)-2-methoxymethyl-pyrrolidin-1-yl)-pyridin-3-yl]-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and 6-((R)-2-methoxymethyl-pyrrolidin-1-yl)-pyridin-3-ylamine. LCMS calcd for C22H21F3N4O3 (m/e) 446, obsd 447 (M+H).

Sources & evidence

ORD record
ord-c8caf58a2b6545d79106176e74804003
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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