2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301337, compound

HRID 2236243Notes

Reaction equation

HRID 2236243 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:19]([N:22]([CH3:30])[C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][N:24]=1)([CH3:21])[CH3:20]>>[CH:19]([N:22]([CH3:30])[C:23]1[N:24]=[CH:25][C:26]([NH:29][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:27][CH:28]=1)([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 16792237HCID 16792237, compound

Product 1

HCID 59301337HCID 59301337, compound

Procedure

With a procedure similar to example 1 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(isopropyl-methyl-amino)-pyridin-3-yl]-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-isopropyl-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C20H19F3N4O2 (m/e) 404, obsd 405 (M+H).

Sources & evidence

ORD record
ord-d2d9f5ef9b1a4030999502806c9ccb1b
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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