2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 57398505, compound

HRID 2236245Notes

Reaction equation

HRID 2236245 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]([CH3:32])[C:27](=[O:31])[CH2:28][O:29][CH3:30])=[N:24][CH:25]=1>>[CH3:30][O:29][CH2:28][C:27]([N:26]([CH3:32])[C:23]1[N:24]=[CH:25][C:20]([NH:19][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:21][CH:22]=1)=[O:31]

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301360HCID 59301360, compound

Product 1

HCID 57398505HCID 57398505, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-acetyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N-(5-amino-pyridin-2-yl)-2-methoxy-N-methyl-acetamide. LCMS calcd for C20H17F3N4O4 (m/e) 434, obsd 435 (M+H).

Sources & evidence

ORD record
ord-894e4a92b8f04bd29fa311807bcda6b1
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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