2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301320, compound

HRID 2236246Notes

Reaction equation

HRID 2236246 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH2:21][C@@H:22]([N:24]([CH3:32])[C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1)[CH3:23]>>[CH3:19][O:20][CH2:21][C@@H:22]([N:24]([CH3:32])[C:25]1[N:26]=[CH:27][C:28]([NH:31][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:29][CH:30]=1)[CH3:23]

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301318HCID 59301318, compound

Product 1

HCID 59301320HCID 59301320, compound

Procedure

With a procedure similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[((S)-2-methoxy-1-methyl-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N2—((S)-2-methoxy-1-methyl-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C21H21F3N4O3 (m/e) 434, obsd 435 (M+H).

Sources & evidence

ORD record
ord-a7e382085667444ebe0528d973d18ab3
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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