2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → 2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[6-(3,3-Difluoroazetidin-1-yl)pyridin-3-yl]amide

HRID 2236248Notes

Reaction equation

HRID 2236248 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[N:22][C:23]([N:26]2[CH2:29][C:28]([F:31])([F:30])[CH2:27]2)=[CH:24][CH:25]=1>>[F:31][C:28]1([F:30])[CH2:29][N:26]([C:23]2[N:22]=[CH:21][C:20]([NH:19][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:25][CH:24]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 52937165HCID 52937165, compound

Product 1

HCID 529367292-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[6-(3,3-Difluoroazetidin-1-yl)pyridin-3-yl]amide

Procedure

With a method similar to example 16 above, 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid-[6-(3,3-difluoroazetidin-1-yl)pyridin-3-yl]amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and 3-amino-6-(3,3-difluoroazetidin-1-yl)pyridine. LCMS calcd for C19H13F5N4O2 m/e 424.33, obsd 425.0 (ES, M+H).

Sources & evidence

ORD record
ord-1daec7bd87b64d328bb0feaed6e315dd
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

Loading…