2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301288, compound

HRID 2236251Notes

Reaction equation

HRID 2236251 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][N:20]([CH2:28][C:29]([F:32])([F:31])[F:30])[C:21]1[N:26]=[CH:25][C:24]([NH2:27])=[CH:23][N:22]=1>>[CH3:19][N:20]([CH2:28][C:29]([F:31])([F:30])[F:32])[C:21]1[N:22]=[CH:23][C:24]([NH:27][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:25][N:26]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301340HCID 59301340, compound

Product 1

HCID 59301288HCID 59301288, compound

Procedure

With a procedure similar to example 16 above, 2-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {2-[methyl-(2,2,2-trifluoro-ethyl)-amino]-pyrimidin-5-yl}-amide was prepared from 2-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N-Methyl-N-(2,2,2-trifluoro-ethyl)-pyrimidine-2,5-diamine. LCMS calcd for C18H13F6N5O2 (m/e) 445, obsd 446 (M+H). The NMR spectrum obtained on the sample is compatible with its structure.

Workup

  1. customThe NMR spectrum obtained on the sample

Sources & evidence

ORD record
ord-2d4b0262faa24ae2ae9503aac16bacd7
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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