5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid → 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide

HRID 2236252Notes

Reaction equation

HRID 2236252 reaction equation
[CH3:1][C:2]1[C:3]([C:13]([OH:15])=O)=[N:4][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH:16]1([N:19]([CH3:27])[C:20]2[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][N:21]=2)[CH2:18][CH2:17]1>>[CH:16]1([N:19]([CH3:27])[C:20]2[N:21]=[CH:22][C:23]([NH:26][C:13]([C:3]3[C:2]([CH3:1])=[N:6][N:5]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[N:4]=3)=[O:15])=[CH:24][CH:25]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 5199365-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acidHCID 43264706N2-cyclopropyl-N2-methyl-pyridine-2,5-diamine

Product 1

HCID 593013895-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide

Procedure

With a procedure similar to example 16 above, 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide was prepared from 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid and N2-cyclopropyl-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C19H20N6O (m/e) 348, obsd 349 (M+H).

Sources & evidence

ORD record
ord-6a359b9c8c984f6bb0b89bc7afa489e7
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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