N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamine → HCID 59301355, compound

HRID 2236255Notes

Reaction equation

HRID 2236255 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([C:17]([OH:19])=O)[N:10]([CH2:12][C:13]([F:16])([F:15])[F:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:20][O:21][CH2:22][CH2:23][N:24]([CH3:32])[C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1>>[CH3:20][O:21][CH2:22][CH2:23][N:24]([CH3:32])[C:25]1[N:26]=[CH:27][C:28]([NH:31][C:17]([C:9]2[N:10]([CH2:12][C:13]([F:14])([F:15])[F:16])[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:8]=2)=[O:19])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 52937159N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamineHCID 59301400HCID 59301400, compound

Product 1

HCID 59301355HCID 59301355, compound

Procedure

With a procedure similar to example 16 above, 5-phenyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazole-3-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 5-phenyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazole-3-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C21H22F3N5O2 (m/e) 433, obsd 434 (M+H). The NMR spectrum obtained on the sample is compatible with its structure.

Workup

  1. customThe NMR spectrum obtained on the sample

Sources & evidence

ORD record
ord-a11121b0a7184c2fbd3e45f9ee223c88
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

Loading…