HCID 59301286, compound → HCID 59301280, compound

HRID 2236262Notes

Reaction equation

HRID 2236262 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]([C:16]([F:19])([F:18])[F:17])=[C:11]([C:13]([OH:15])=O)[N:12]=1.[CH:20]1([CH2:23][O:24][CH2:25][CH2:26][N:27]([CH3:35])[C:28]2[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][N:29]=2)[CH2:22][CH2:21]1>>[CH:20]1([CH2:23][O:24][CH2:25][CH2:26][N:27]([CH3:35])[C:28]2[N:29]=[CH:30][C:31]([NH:34][C:13]([C:11]3[N:12]=[C:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[Br:1])[O:9][C:10]=3[C:16]([F:19])([F:18])[F:17])=[O:15])=[CH:32][CH:33]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 59301286HCID 59301286, compoundHCID 59301376HCID 59301376, compound

Product 1

HCID 59301280HCID 59301280, compound

Procedure

With a procedure similar to example 16 above, 2-(2-bromo-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-cyclopropylmethoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-(2-bromo-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-(2-cyclopropylmethoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C23H22BrF3N4O3 (m/e) 539, obsd 540 (M+H).

Sources & evidence

ORD record
ord-806398eaf6b9499fa9f5444b67084608
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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