2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 52936728, compound

HRID 2236279Notes

Reaction equation

HRID 2236279 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[N:22][C:23]([N:26]2[CH2:30][CH2:29][CH:28]([OH:31])[CH2:27]2)=[N:24][CH:25]=1>>[OH:31][CH:28]1[CH2:29][CH2:30][N:26]([C:23]2[N:24]=[CH:25][C:20]([NH:19][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:21][N:22]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 52937163HCID 52937163, compound

Product 1

HCID 52936728HCID 52936728, compound

Procedure

With a method similar to example 43 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid-[2-(3-hydroxypyrrolidin-1-yl)pyrimidin-5-yl]amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N-(5-amino-pyrimidin-2-yl)-pyrrolidin-3-ol. LCMS calcd for C19H16F3N5O3 m/e 419.37, obsd 420.0 (ES, M+H).

Sources & evidence

ORD record
ord-18825afb78fc499d9cd5da98d979a997
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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