2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301426, compound

HRID 2236286Notes

Reaction equation

HRID 2236286 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[N:22][C:23]([NH:26][C@@H:27]([CH3:30])[CH2:28][OH:29])=[N:24][CH:25]=1>>[OH:29][CH2:28][C@@H:27]([NH:26][C:23]1[N:24]=[CH:25][C:20]([NH:19][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:21][N:22]=1)[CH3:30]

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301327HCID 59301327, compound

Product 1

HCID 59301426HCID 59301426, compound

Procedure

With a procedure similar to example 43 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [2-((S)-2-hydroxy-1-methyl-ethylamino)-pyrimidin-5-yl]-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and (S)-2-(5-amino-pyrimidin-2-ylamino)-propan-1-ol. LCMS calcd for C18H16F3N5O3 (m/e) 407, obsd 408 (M+H).

Sources & evidence

ORD record
ord-ef7c082363b5496a9c065c0a7d81ea72
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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