6-(Morpholino)pyridin-3-amine → HCID 59301424, compound

HRID 2236294Notes

Reaction equation

HRID 2236294 reaction equation
O=C1CCC(=O)N1O[C:9]([C:11]1[O:15][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:13][C:12]=1[CH2:22][CH2:23][S:24][CH3:25])=[O:10].[N:26]1([C:32]2[N:37]=[CH:36][C:35]([NH2:38])=[CH:34][CH:33]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[N:26]1([C:32]2[N:37]=[CH:36][C:35]([NH:38][C:9]([C:11]3[O:15][C:14]([C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)=[N:13][C:12]=3[CH2:22][CH2:23][S:24][CH3:25])=[O:10])=[CH:34][CH:33]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 1040596-(Morpholino)pyridin-3-amineHCID 59301321HCID 59301321, compound

Product 1

HCID 59301424HCID 59301424, compound

Procedure

With a procedure similar to example 50 above, 4-(2-methylsulfanyl-ethyl)-2-phenyl-oxazole-5-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide was prepared from 4-(2-methylsulfanyl-ethyl)-2-phenyl-oxazole-5-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester and 6-morpholin-4-yl-pyridin-3-ylamine. LCMS calcd for C22H24N4O3S (m/e) 424, obsd 425 (M+H).

Sources & evidence

ORD record
ord-0a634441404b4efd8088eb4d0c99935b
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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