N2-cyclopropyl-N2-methyl-pyridine-2,5-diamine → 2-(2-Chloro-phenyl)-4-propyl-oxazole-5-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide

HRID 2236304Notes

Reaction equation

HRID 2236304 reaction equation
O=C1CCC(=O)N1O[C:9]([C:11]1[O:15][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[N:13][C:12]=1[CH2:23][CH2:24][CH3:25])=[O:10].[CH:26]1([N:29]([CH3:37])[C:30]2[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][N:31]=2)[CH2:28][CH2:27]1>>[CH:26]1([N:29]([CH3:37])[C:30]2[N:31]=[CH:32][C:33]([NH:36][C:9]([C:11]3[O:15][C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[Cl:22])=[N:13][C:12]=3[CH2:23][CH2:24][CH3:25])=[O:10])=[CH:34][CH:35]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 43264706N2-cyclopropyl-N2-methyl-pyridine-2,5-diamineHCID 593014372-(2-Chloro-phenyl)-4-propyl-oxazole-5-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Product 1

HCID 593014392-(2-Chloro-phenyl)-4-propyl-oxazole-5-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide

Procedure

With a procedure similar to example 50 above, 2-(2-chloro-phenyl)-4-propyl-oxazole-5-carboxylic acid [6-(cyclopropyl-methyl-amino)-pyridin-3-yl]-amide was prepared from 2-(2-chloro-phenyl)-4-propyl-oxazole-5-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester and N2-cyclopropyl-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C22H23ClN4O2 (m/e) 410, obsd 411 (M+H).

Sources & evidence

ORD record
ord-2acf88f80f5147daaf9d1557e6d8c646
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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