Triethylamine → HCID 59301396, compound

Participants

Reaction Steps

(2-Ethoxy-ethyl)-methyl-(5-nitro-pyridin-2-yl)-amine (150 mg, 0.666 mmol) was hydrogenated as above and reacted with 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (171 mg, 0.666 mmol), Et3N (464 uL, 3.3 mmol) and BOP (309 mg. 0.699 mmol). Following work-up as above, the crude material was purified by flash chromatography to yield 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-ethoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide as a yellow solid (194 mg). ES-MS calcd for C21H21F3N4O3 (m/e) 434.42, obsd 435.1 (M+H).

Provenance & Evidence