2-Amino-2,3-dimethylbutyronitrile → HCID 59301829, compound

HRID 2236355Notes

Reaction equation

HRID 2236355 reaction equation
[C:1]([C:3]([NH2:8])([CH3:7])[CH:4]([CH3:6])[CH3:5])#[N:2].[CH2:9]([O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][C:14]=1[F:22])[C:10]#[CH:11]>>[C:1]([C:3]([NH:8][C:17](=[O:18])[C:16]1[CH:20]=[CH:21][C:13]([O:12][CH2:9][C:10]#[CH:11])=[C:14]([F:22])[CH:15]=1)([CH3:7])[CH:4]([CH3:6])[CH3:5])#[N:2]

Participants

3

Reactant 2

HCID 943552-Amino-2,3-dimethylbutyronitrileHCID 574456843-Fluoro-4-(2-propynyloxy)benzoyl chloride

Product 1

HCID 59301829HCID 59301829, compound

Procedure

According to the same method as that of Production Example 1, 1-cyano-1,2-dimethylpropylamine was used in place of 2,2-dimethylpropylamine, and 4-(2-propynyloxy)-3-fluorobenzoyl chloride was used in place of 4-(2-propynyloxy)-3-methoxybenzoyl chloride to obtain N-(1-cyano-1,2-dimethylpropyl)-3-fluoro-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 27 of the present invention) represented by the formula:

Sources & evidence

ORD record
ord-a59b813bcac841f88af631f4e28e245a
Source dataset
uspto-grants-2010_05
Patent number
US07714168B2

Reaction notes

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