HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoformate → 4-Methoxymethylene-4H-isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 1,3(2H,4H)-isoquinolinedione | HCID 349435 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 4-Methoxymethylene-4H-isoquinoline-1,3-dione | HCID 68692337 | — |
Reaction Conditions
| Temperature | 125 °C |
|---|
Reaction Steps
Trimethyl orthoformate (5.648 mL, 51.56 mmol) is added to a solution of 4H-Isoquinoline-1,3-dione (4 g, 24.82 mmol) in acetic anhydride (41.6 mL) and N,N-dimethylformamide (10.4 mL). After it is heated at 125° C. for 50 min, it is cooled and filtered to collected 3.698 g (73%) of the title compound as a yellow solid. mp 260-261° C.; MS (ESI) m/z 204.04 (M+1). Found: C, 58.34; H, 3.63; N, 10.21.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4d760945aec9449e8f151cff8b929f14 |
| Source note | uspto-grants-2010_05 |