Acetic Acid → tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

Participants

Reaction Steps

A mixture of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (307 mg, 1 mmol), iron powder (196 mg, 3.5 mmol), acetic acid (0.4 mL, 7 mmol) and methanol (5 mL) is heated at 66 C until no nitro compound left. After it is dried it is treated with ethyl acetate and water, and filtered through a pad of celite. The ethyl acetate layer is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution, and then dried to yield the title compound.

Provenance & Evidence