Acetic Acid → 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine

Participants

Role	Name	HCID	Charge
Reactant	Acetic Acid	HCID 176	—
Reactant	2-(4-Methylpiperazin-1-yl)-5-nitropyrimidine	HCID 68694824	—
Catalyst	Iron	HCID 23925	—
Solvent	Methanol	HCID 887	—
Product	2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine	HCID 56828412	78.1%

Reaction Steps

A mixture of 2-(4-methyl-piperazin-1-yl)-5-nitro-pyrimidine (446 mg, 2 mmol), iron powder (432 mg, 7.6 mmol), acetic acid (0.884 mL, 14 mmol) in methanol (8 mL) is heated at 65 C for 2 h. It is worked up as before to yield 302 mg (78%) of the title compound. MS (ESI) m/z 194 (M+H)+1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07713994B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-0cc379c496e449888e8d2cc4d44eb56d
Source note	uspto-grants-2010_05