HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 2-Furan-3-yl-5-hydroxy-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | Furan-3-boronic acid | HCID 2734358 | — |
| Reactant | 5-Hydroxy-2-iodobenzonitrile | HCID 68696052 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Furan-3-yl-5-hydroxy-benzonitrile | HCID 59300111 | — |
Reaction Steps
5-Hydroxy-2-iodo-benzonitrile (70 mg, 0.29 mmol), Pd2(dba)3.CHCl3(25 mg, 0.01 mmol) and P(tBu)3 (0.05 mL, 10% in hexane, 0.016 mmol), 3-furanboronic acid (40 mg, 0.36 mmol) and CsF (200 mg, 1.32 mmol) were suspended in N,N-dimethylformamide (5 mL). The mixture is then degassed and stirred at room temperature for 4 hours. After aqueous workup, the residue is purified with chromatography and directly employed in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-fe0d95519f4a4c3fa213313ff6d8e065 |
| Source note | uspto-grants-2010_05 |