Hydrochloric Acid → (1H-indol-4-yl)methanamine

Participants

Reaction Steps

An amount of 1H-Indole-4-carbaldehyde O-methyl-oxime (50 mg, 0.30 mmol) is dissolved in ethanol (5 mL). Then hydrogen chloride (0.217 mL) is added, followed by 10% Pd/C (5.0 mg). After hydrogenation at 35 psi for 3 h, the solution is filtered through Celite and evaporated to dryness. The residue is recrystallized from ethyl acetate to give 42 mg of crude product as an orange residue. MS (ESI) m/z 147.2 (M+1).

Provenance & Evidence