Urea → 6-tert-butyl-4H-isoquinoline-1,3-dione

Participants

Reaction Steps

An amount of 1.5 g (6.35 mmol) of 4-tert-butyl-2-(carboxymethyl)benzoic acid and urea (763 mg, 12.7 mmol) were heated neat at 145-148° C. for 1.5 hours. The mixture is cooled to room temperature and 200 mL of chloroform is added and washed 3× with water, dried over sodium sulfate and evaporated. The crude product is purified by column chromatography 4% methanol methylene chloride to give 580 mg (41% yield) of the product as a brown solid. MS (ESI) m/z 218.2 (M+1).

Provenance & Evidence