Piperidine → 4-(N-piperidinomethylcarbonyl-N-methyl-amino)-nitrobenzene

Participants

Reaction Steps

A solution of 2.82 g (10.3 mmol) of 2-Bromo-N-methyl-N-(4-nitrophenyl)-acetamide and 2.08 g (20.6 mmol) of Et3N in 30 mL of CH2Cl2 at 0° C. under N2 is treated with 0.875 g (10.3 mmol) of piperidine for 5 min at 0° C. and refluxed for 1.25 h. The cooled reaction mixture is washed with H2O, treated with Darco, dried (MgSO4) and evaporated to give 3.00 g (100%) of brown oil. 1H NMR (DMSO-d6) δ 8.25 (d, 2H, J=6.9 Hz), 7.63 (d, 2H, J=6.9 Hz), 3.30 (s, 3H), 3.09 (s, 2H), 2.25 (s, 4H), 1.31 (m, 6H); MS (ESI) m/z 278.0 (M+H).

Provenance & Evidence