1,1'-Carbonyldiimidazole → HCID 59300334, compound

Participants

Reaction Steps

A solution of 0.670 g (2.61 mmol) of 4-Carbamoylmethyl-2-phenyl-pyrimidine-5-carboxylic Acid and 0.528 g (3.26 mmol) of CDI in 20 mL of N,N-dimethylformamide is stirred overnight at 25° C. The solvent is evaporated and the residue is washed with Et2O (3×). The insoluble material is boiled with CHCl3, collected, washed with hot CHCl3 and Et2O and dried in vacuo to give 0.372 g (60%) of yellow-orange crystals: mp 216-217.5° C. (dec); 1H NMR (DMSO-d6) δ 8.99 (s, 1H), 8.41 (m, 2H), 7.56 (m, 4H), 5.45 (s, 2H); HRMS (ESI) m/e calcd for C13H9N3O2 240.07645. found 240.07652 (M+H)+1. Analysis for C13H9N3O2.0.25H2O: Calcd: C, 64.05; H, 3.94; N, 17.24. Found: C, 63.67; H, 3.91; N, 17.38.

Provenance & Evidence