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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236469Generated: October 31, 2026

3-Hydroxy-4-phenylbenzylamine → 4-Aminomethyl-4'-fluoro-biphenyl-2-ol

https://huagongshe.com/reaction/2236469

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxy-4-phenylbenzylamineHCID 23143856—
Reactant4-Azidomethyl-4'-fluoro-biphenyl-2-olHCID 59300024—
Product4-Aminomethyl-4'-fluoro-biphenyl-2-olHCID 5929992254%

Reaction Steps

Following the same procedure for the preparation of 4-Aminomethyl-biphenyl-2-ol, the title compound is prepared from 4-Azidomethyl-4′-fluoro-biphenyl-2-ol (crude material from the previous step) in 54% yield (over 4 steps). MS (ESI): 218 (M+1)+1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07713994B2
Source datasetuspto-grants-2010_05
ORD IDord-479d3efa403941b8aa0cda325af43117
Source noteuspto-grants-2010_05