HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)furan → 6-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)furan | HCID 4393688 | — |
| Reactant | 4-methoxymethylene-6-bromo-4H-isoquinoline-1,3-dione | HCID 68692764 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dione | HCID 68696367 | 68% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (1.24 g, 4.4 mmol) and PdCl2(PPh3)2 (200 mg, 0.28 mmol) and 2-furyltributyltin (2 g, 5.6 mmol) in N,N-dimethylformamide (20 mL) is degassed and heated at 100° C. for 1 hour. Upon cooling to room temperature, the product precipitated out. After filtration, the precipitate is washed with Et2O and dried to provide the desired product (800 mg, 68%). MS (ESI): 270.1 (M+1)+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-588e3cbfbf4a4d1cb978aac0414568c0 |
| Source note | uspto-grants-2010_05 |