Potassium Carbonate → HCID 59300165, compound

Participants

Reaction Steps

2-Pyrrolidin-2-yl-propan-2-ol (100 mg, 0.78 mmol) is dissolved in CH3CN (5 mL) to which K2CO3 (300 mg, 2.17 mmol) and p-nitrobenzylbromide (250 mg, 1.16 mmol) were added. The resulting mixture is stirred until MS suggested no starting alcohol is present. The suspension is filtered to remove the potassium salts and the acetonitrile is removed under vacuum. The residue is purified to afford the product (105 mg, 51%). 1H NMR (300 MHz, CDCl3) 8.18 (2H, d, J=8.7 Hz), 7.54 (2H, d, J=8.7 Hz), 4.25 (1H, d, J=15 Hz), 3.72 (1H, d, J=15 Hz), 2.90-2.95 (1H, m), 2.76-2.80 (1H, m), 2.28-2.38 (2H, m), 1.71-1.91 (4H, m), 1.24 (3H, s), 1.20 (3H, s).

Provenance & Evidence