HCID 59300355, compound → HCID 59299825, compound

Participants

Reaction Steps

Allyl-[1-(4-bromo-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester (300 mg, 0.82 mmol) in CH2Cl2 (10 mL) is degassed and the 2nd generation of Grubb's catalyst (40 mg, 5%) is added under N2. The reaction did not proceed at room temperature and the mixture is brought to reflux. TLC is used to determine complete reaction of the olefin. The mixture is loaded onto a column and purified to provide the desired product (208 mg, 75%). 1H NMR (300 MHz, CDCl3) ∂7.43(2H, d, J=8.1 Hz), 7.17-7.26 (2H, m), 5.89-5.95 (1H, m), 5.34-5.58 (2H, m), 4.14-4.36 (1H, m), 3.35-3.44 (1H, m), 2.73-2.81 (1H, m), 2.41-2.62 (1H, m), 1.48 (9H, s).

Provenance & Evidence