HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 1-(4-Bromo-benzyl)-2-ethoxymethyl-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (1-(4-Bromobenzyl)pyrrolidin-2-yl)methanol | HCID 44827912 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Bromo-benzyl)-2-ethoxymethyl-pyrrolidine | HCID 68692922 | — |
Reaction Steps
[1-(4-Bromo-benzyl)-pyrrolidin-2-yl]-methanol (269 mg, 1.0 mmol) and EtI (234 mg, 1.5 mmol) is mixed at 0° C. in DMF (DMF) (10 mL). To this mixture is then added NaH (60 mg, 60% suspension in mineral oil, 1.5 mmol). The resulting mixture is stirred at room temperature for 1 h before aqueous workup. The resulting residue is directly used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-abbdf561bc5a4c39a4ab45cb92ab78b2 |
| Source note | uspto-grants-2010_05 |