Tert-butyl 2-(4-aminophenyl)pyrrolidine-1-carboxylate → 4-(2-Ethoxymethyl-pyrrolidin-1-ylmethyl)-phenylamine

Participants

Reaction Steps

Using the same procedure described for the preparation of 2-(4-Amino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester, the title compound is prepared from 1-(4-Bromo-benzyl)-2-ethoxymethyl-pyrrolidine (using the crude product obtained in the previous step) in 47% yield (two steps, based on crude residue, ˜85%).

Provenance & Evidence